Spravato Treatment in North Texas
Spravato helps restore balance, clarity, and connection—guided by trusted care across North Texas.
Spravato (esketamine) is an FDA-approved nasal spray treatment for treatment-resistant depression and major depressive disorder with acute suicidal ideation. It is administered in a REMS-certified clinic over a 4-week induction phase (twice weekly) followed by maintenance dosing, and is covered by most commercial insurance, Medicare, and Medicaid for qualifying patients.
Medically reviewed by Dr. Aaron Brown, DO — Medical Director & Board-Certified Psychiatrist · Last reviewed October 2026 · Updated October 7, 2026
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What Is Spravato Treatment?
Spravato is a nasal esketamine spray used with psychotherapy when other depression treatments fail. You self-administer two sprays under supervision in NeuroGlow North Texas clinic, and relief often comes within hours.
After dosing, you rest under observation, then debrief with your therapist. Simple at-home steps, like brief breathing or jotting thoughts, help extend the lift into your daily routine.
The Clinical Evidence Behind Spravato
Spravato (esketamine) earned FDA approval on the strength of large, peer-reviewed clinical trials. A few of the pivotal studies:
- TRANSFORM-2 (Popova et al., 2019, American Journal of Psychiatry): Esketamine nasal spray combined with a newly initiated oral antidepressant produced significantly greater improvement in treatment-resistant depression than an antidepressant plus placebo.
- TRANSFORM-1 (Fedgchin et al., 2019, International Journal of Neuropsychopharmacology): A Phase 3 trial supporting the efficacy and safety of esketamine nasal spray for treatment-resistant depression.
- SUSTAIN-1 (Daly et al., 2019, JAMA Psychiatry): Continued esketamine treatment significantly delayed relapse among patients who had initially responded, supporting its role in longer-term maintenance.
- ASPIRE-I (Fu et al., 2020, Journal of Clinical Psychiatry): Esketamine rapidly reduced depressive symptoms in adults with major depressive disorder experiencing active suicidal ideation.
At NeuroGlow, every Spravato treatment is administered in-office under the supervision of our board-certified medical team, consistent with the FDA REMS safety program.
What are Spravato Treatment Protocols?
Feel supported, informed, and fully cared for through every step of your Spravato treatment, guided by experts at NeuroGlow and following structured Spravato treatment protocols tailored to you across trusted locations in North Texas.
Here are the main steps in Spravato treatment at NeuroGlow:
NeuroGlow provides Spravato (esketamine) treatment at three convenient DFW locations — Spravato in Fort Worth, TX, Spravato treatment in McKinney, and Spravato in Flower Mound.
- Consultation: Discuss your history, set goals, and prepare expectations with your dedicated therapist.
- Self-Administration: You gently administer two sprays under care, guided by one of our psychiatric nurse practitioners.
- Guided Observation: Relax under supervision as professionals monitor effects, creating a secure healing environment.
- Insight Integration:Explore emerging thoughts with therapy, then practice simple at-home techniques to reinforce progress.
- Spravato treatment typically lasts 8 to 16 weeks, beginning with twice-weekly sessions and tapering over time. Each visit takes about two hours, including a calm observation period to ensure your comfort and safety.
Why Spravato Matters in North Texas?
- Spravato combines fast-acting relief with guided support, helping you move beyond depression.
- Lifts low moods within hours, offering renewed hope.
- Administered safely under expert medical supervision.
- Integrated with therapy to support emotional breakthroughs.
- Practical at-home tools help maintain relief between sessions.
What is Spravato Treatment Pricing?
Curious about Spravato treatment pricing? At NeuroGlow, we keep it simple, supportive, and transparent from day one.
- Spravato is covered by insurance for those who qualify.
- Includes full mental health evaluation and intake consultation.
- Private treatment rooms with expert observation and care.
- Many pay little or nothing out-of-pocket: assistance is available.
Spravato Cost With Insurance
Because Spravato is FDA-approved for treatment-resistant depression, it is covered by most major commercial plans when their criteria are met — your exact copay depends on your plan, and we confirm it for you in writing before your first treatment. We work with major carriers including Blue Cross Blue Shield, Aetna, Cigna, UnitedHealthcare, Optum, and Humana, and we are in-network with TRICARE, including TriWest-administered plans. We verify your benefits for free, with no commitment, so you know your out-of-pocket cost before you begin. See our full insurance details →
Spravato is covered by most commercial insurance plans. Your copay depends on your plan and we confirm it in writing before your first session. Eligible, commercially insured patients may pay as low as $10 per treatment through the SPRAVATO withMe savings program. Medicare, Medicaid and TRICARE plans are not eligible for withMe; TRICARE, including TriWest, is in-network with NeuroGlow. We’ll verify your benefits and walk you through SPRAVATO withMe enrollment.
Dedicated Spravato guides for your city: Flower Mound · McKinney · Fort Worth · Frisco · Prosper & Celina · Lewisville · Denton · Highland Village, Argyle & Lantana
Spravato vs. IV Ketamine
Both are offered across our DFW clinics. Your provider will help you choose the right fit.
Am I a Candidate for Spravato?
You may be a good candidate for Spravato if you are:
- An adult (18+) with major depressive disorder
- Someone who has tried two or more antidepressants without adequate relief (treatment-resistant depression)
- Living with major depressive disorder and experiencing suicidal thoughts
The only way to know for sure is a quick conversation with our physician-led team — they will confirm whether Spravato is right for you.
Call 469-218-4410 to see if you qualifyReal Stories. Real Progress.
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Frequently Asked Questions About Spravato Therapy
How does Spravato work?
Spravato is esketamine, a single isomer of the ketamine molecule, delivered as a nasal spray. It works through NMDA receptor modulation to stimulate neuroplasticity, the brain's ability to form new neural connections. This mechanism allows Spravato to work much faster than traditional antidepressants, with many patients feeling improvement within the first few sessions.
Who is a candidate for Spravato?
Spravato is FDA-approved for adults with treatment-resistant depression (TRD), defined as depression that hasn't responded to at least two different antidepressants. It's also approved for adults with major depressive disorder and acute suicidal ideation. Your candidacy is determined during a free consultation with our medical team.
Is Spravato covered by insurance?
Yes. Spravato is covered by most major insurance plans for adults with treatment-resistant depression. NeuroGlow accepts Blue Cross Blue Shield, Aetna, Cigna, UnitedHealthcare, Humana, and Optum, and is in-network with TRICARE, including TriWest-administered plans. We provide a free benefits verification before treatment begins, and your copay depends on your plan; eligible, commercially insured patients may pay as low as $10 per treatment through SPRAVATO withMe.
What does a Spravato session look like?
You'll self-administer the Spravato nasal spray in our clinic under direct medical supervision. After the dose, you'll relax in a quiet, comfortable space for a two-hour monitored recovery period, which is required by the FDA's REMS (Risk Evaluation and Mitigation Strategy) protocol. We monitor vitals throughout and have providers nearby the entire time.
How is Spravato different from IV ketamine?
Both work through similar NMDA receptor mechanisms, but they differ in three important ways. Spravato is the esketamine isomer, delivered as a nasal spray, and FDA-approved for treatment-resistant depression, so it's typically insurance-covered. IV ketamine uses the full racemic molecule, delivered intravenously, and is used off-label. Spravato focuses on depression; IV ketamine covers broader application including PTSD, anxiety, OCD, and chronic pain.
IV Ketamine vs Spravato: A Quick Comparison
Both treatments work by modulating the NMDA-glutamate system, but they differ in several practical ways.
| Feature | IV Ketamine | Spravato (Esketamine) |
|---|---|---|
| Active molecule | Racemic ketamine (both R and S enantiomers) | Esketamine (S-enantiomer only) |
| FDA status | Off-label for depression (approved as anesthetic) | FDA-approved for TRD and MDD with acute suicidal ideation |
| Route | IV infusion (~45 minutes) | Nasal spray (self-administered under supervision) |
| Setting | Any licensed clinic with IV capability | REMS-certified clinic only |
| Insurance | Self-pay (HSA/FSA + CareCredit accepted) | Covered by most commercial plans, Medicare, Medicaid, TRICARE (TriWest) |
| Induction phase | 6 infusions over 2 to 3 weeks | 8 doses over 4 weeks (twice weekly) |
| Maintenance | Booster infusions as needed (typically every 2-8 weeks) | Weekly tapering to biweekly |
| Response timing | Often within 1 to 2 infusions | Most patients within 2 weeks |
| Typical cost | $3,500 for full induction series | Copay varies by plan; as low as $10 per treatment for eligible, commercially insured patients (SPRAVATO withMe) |
| FDA-approved use cases | Anesthesia (off-label for depression, PTSD, anxiety, pain) | Treatment-resistant depression + MDD with acute suicidal ideation |
Our expert team is eager to embark on this journey with you, providing personalized and compassionate care that exceeds your expectations.